International Journal of Fundamental & Applied SciencesISSN 2278-140420176434http://bma.org.in/ijfas.aspx@2017 BioMedAsia All right reserved In silico designing of DASM with Pyrazofurin, a possible drug candidate for AnthraxInt. J. Fund. Appl. Sci. Vol. 6, No. 4 (2017) 34-39Manuscript: received 12 Nov, 2017 revised 21 Dec 2017 accepted 27 Dec, 2017ORIGINAL ARTICLEPrashantha Karunakar,Department of Biotechnology, PES University, Banashankari III Stage, Bangalore ? 560085, Karnataka India.K V Shiva Kumar,Department of Biotechnology, PES University, Banashankari III Stage, Bangalore ? 560085, Karnataka India.C Sunil Kumar,Department of Biotechnology, PES University, Banashankari III Stage, Bangalore ? 560085, Karnataka India.V Krishna Murthy,Department of Biotechnology, PES University, Banashankari III Stage, Bangalore ? 560085, Karnataka India.C R GirijaDepartment of Chemistry, Government Science College, Nrupatunga Road, Bangalore?560001, Karnataka IndiaBacillus anthracis is a notorious occupational zoonotic agent causing anthrax to veterinarians. In this study, for the purpose of lead development, Dehydro Andrographolide Succinic acid Monoester (DASM) inhibitor of Furin was selected as a template.Anthrax infection is highly lethal in its most virulent form and produces a combination of three endotoxins namely Protective antigen, Lethal factor and Edema factor.Furin is involved in other diseases, DASM was modified by adding anti-cancer, anti-inflammatory, anti-tuberculosis and anti-viral groups. Bacillus anthracis, Dehydro Andrographolide Succinic acid Monoester, Furin, Protective antigen, Lethal fator